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Preterm Delivery Disrupts the Developmental Program of the Cerebellum

A rapid growth in human cerebellar development occurs in the third trimester, which is impeded by preterm delivery. The goal of this study was to characterize the impact of preterm delivery on the developmental program of the human cerebellum. Still born infants, which meant that all development up...

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Autores principales: Haldipur, Parthiv, Bharti, Upasna, Alberti, Corinne, Sarkar, Chitra, Gulati, Geetika, Iyengar, Soumya, Gressens, Pierre, Mani, Shyamala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157376/
https://www.ncbi.nlm.nih.gov/pubmed/21858122
http://dx.doi.org/10.1371/journal.pone.0023449
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author Haldipur, Parthiv
Bharti, Upasna
Alberti, Corinne
Sarkar, Chitra
Gulati, Geetika
Iyengar, Soumya
Gressens, Pierre
Mani, Shyamala
author_facet Haldipur, Parthiv
Bharti, Upasna
Alberti, Corinne
Sarkar, Chitra
Gulati, Geetika
Iyengar, Soumya
Gressens, Pierre
Mani, Shyamala
author_sort Haldipur, Parthiv
collection PubMed
description A rapid growth in human cerebellar development occurs in the third trimester, which is impeded by preterm delivery. The goal of this study was to characterize the impact of preterm delivery on the developmental program of the human cerebellum. Still born infants, which meant that all development up to that age had taken place in-utero, were age paired with preterm delivery infants, who had survived in an ex-utero environment, which meant that their development had also taken place outside the uterus. The two groups were assessed on quantitative measures that included molecular markers of granule neuron, purkinje neuron and bergmann glia differentiation, as well as the expression of the sonic hedgehog signaling pathway, that is important for cerebellar growth. We report that premature birth and development in an ex-utero environment leads to a significant decrease in the thickness and an increase in the packing density of the cells within the external granular layer and the inner granular layer well, as a reduction in the density of bergmann glial fibres. In addition, this also leads to a reduced expression of sonic hedgehog in the purkinje layer. We conclude that the developmental program of the cerebellum is specifically modified by events that follow preterm delivery.
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spelling pubmed-31573762011-08-19 Preterm Delivery Disrupts the Developmental Program of the Cerebellum Haldipur, Parthiv Bharti, Upasna Alberti, Corinne Sarkar, Chitra Gulati, Geetika Iyengar, Soumya Gressens, Pierre Mani, Shyamala PLoS One Research Article A rapid growth in human cerebellar development occurs in the third trimester, which is impeded by preterm delivery. The goal of this study was to characterize the impact of preterm delivery on the developmental program of the human cerebellum. Still born infants, which meant that all development up to that age had taken place in-utero, were age paired with preterm delivery infants, who had survived in an ex-utero environment, which meant that their development had also taken place outside the uterus. The two groups were assessed on quantitative measures that included molecular markers of granule neuron, purkinje neuron and bergmann glia differentiation, as well as the expression of the sonic hedgehog signaling pathway, that is important for cerebellar growth. We report that premature birth and development in an ex-utero environment leads to a significant decrease in the thickness and an increase in the packing density of the cells within the external granular layer and the inner granular layer well, as a reduction in the density of bergmann glial fibres. In addition, this also leads to a reduced expression of sonic hedgehog in the purkinje layer. We conclude that the developmental program of the cerebellum is specifically modified by events that follow preterm delivery. Public Library of Science 2011-08-17 /pmc/articles/PMC3157376/ /pubmed/21858122 http://dx.doi.org/10.1371/journal.pone.0023449 Text en Haldipur et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Haldipur, Parthiv
Bharti, Upasna
Alberti, Corinne
Sarkar, Chitra
Gulati, Geetika
Iyengar, Soumya
Gressens, Pierre
Mani, Shyamala
Preterm Delivery Disrupts the Developmental Program of the Cerebellum
title Preterm Delivery Disrupts the Developmental Program of the Cerebellum
title_full Preterm Delivery Disrupts the Developmental Program of the Cerebellum
title_fullStr Preterm Delivery Disrupts the Developmental Program of the Cerebellum
title_full_unstemmed Preterm Delivery Disrupts the Developmental Program of the Cerebellum
title_short Preterm Delivery Disrupts the Developmental Program of the Cerebellum
title_sort preterm delivery disrupts the developmental program of the cerebellum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157376/
https://www.ncbi.nlm.nih.gov/pubmed/21858122
http://dx.doi.org/10.1371/journal.pone.0023449
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