Cargando…

Plasma L-Cystine/L-Glutamate Imbalance Increases Tumor Necrosis Factor-Alpha from CD14+ Circulating Monocytes in Patients with Advanced Cirrhosis

BACKGROUND AND AIMS: The innate immune cells can not normally respond to the pathogen in patients with decompensated cirrhosis. Previous studies reported that antigen-presenting cells take up L-Cystine (L-Cys) and secrete substantial amounts of L-Glutamate (L-Glu) via the transport system Xc- (4F2hc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kakazu, Eiji, Ueno, Yoshiyuki, Kondo, Yasuteru, Inoue, Jun, Ninomiya, Masashi, Kimura, Osamu, Wakui, Yuta, Fukushima, Koji, Tamai, Keiichi, Shimosegawa, Tooru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157377/ https://www.ncbi.nlm.nih.gov/pubmed/21858100 http://dx.doi.org/10.1371/journal.pone.0023402

Ejemplares similares

Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell
por: Kakazu, Eiji, et al.
Publicado: (2013)

The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis
por: Kakazu, Eiji, et al.
Publicado: (2012)

Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers
por: Ninomiya, Masashi, et al.
Publicado: (2013)

Hepatitis B Surface Antigen Could Contribute to the Immunopathogenesis of Hepatitis B Virus Infection
por: Kondo, Yasuteru, et al.
Publicado: (2013)

Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT
por: Kondo, Yasuteru, et al.
Publicado: (2011)

Biological Significance of HCV in Various Kinds of Lymphoid Cells
por: Kondo, Yasuteru, et al.
Publicado: (2012)

Toll-Like Receptors Signaling Contributes to Immunopathogenesis of HBV Infection
por: Kondo, Yasuteru, et al.
Publicado: (2011)

Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma
por: Kimura, Osamu, et al.
Publicado: (2014)

Gastroesophageal Variceal Bleeding Successfully Controlled by Partial Splenic Embolization
por: Kogure, Takayuki, et al.
Publicado: (2017)

PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections
por: Ninomiya, Masashi, et al.
Publicado: (2012)

Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis
por: Ninomiya, Masashi, et al.
Publicado: (2012)

HCV Infection Enhances Th17 Commitment, Which Could Affect the Pathogenesis of Autoimmune Diseases
por: Kondo, Yasuteru, et al.
Publicado: (2014)

Significant Roles of Regulatory T Cells and Myeloid Derived Suppressor Cells in Hepatitis B Virus Persistent Infection and Hepatitis B Virus-Related HCCs
por: Kondo, Yasuteru, et al.
Publicado: (2015)

1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial
por: Kondo, Yasuteru, et al.
Publicado: (2013)

Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance
por: Singh, Vikas, et al.
Publicado: (2016)

Management of chronic hepatitis B patients: Efficacy & limitation of nucleos(t)ide analogues
por: Inoue, Jun, et al.
Publicado: (2011)

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission
por: Fukuyama, Kouji, et al.
Publicado: (2018)

CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE
por: Earle, David P., et al.
Publicado: (1941)

Acute-onset Autoimmune Hepatitis in a Young Woman with Type 1 Diabetes Mellitus
por: Takai, Satoshi, et al.
Publicado: (2018)

Inhibitory effect of silibinin on hepatitis B virus entry
por: Umetsu, Teruyuki, et al.
Publicado: (2018)

PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma
por: Kimura, Osamu, et al.
Publicado: (2012)

Increased expression of cystine/glutamate antiporter in multiple sclerosis
por: Pampliega, Olatz, et al.
Publicado: (2011)

High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
por: Thomas, Ajit G., et al.
Publicado: (2015)

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
por: Honma, Midori, et al.
Publicado: (2018)

Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli
por: Ohtsu, Iwao, et al.
Publicado: (2015)

Change of cystine/glutamate antiporter expression in ethanol-dependent rats
por: Peana, Alessandra T., et al.
Publicado: (2014)

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues
por: Martis, Renita M., et al.
Publicado: (2020)

PD-L1(+)MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment
por: Iwata, Tomoaki, et al.
Publicado: (2016)

Effects of (L)-Cystine and (L)-Theanine Supplementation on the Common Cold: A Randomized, Double-Blind, and Placebo-Controlled Trial
por: Kurihara, Shigekazu, et al.
Publicado: (2010)

Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and COVID-19 pathophysiology
por: Páez-Franco, José C., et al.
Publicado: (2022)

Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice
por: Taguchi, Kumiko, et al.
Publicado: (2007)

The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?
por: Gallagher, Martin
Publicado: (2020)

Crystal structure of seleno-l-cystine dihydrochloride
por: Görbitz, Carl Henrik, et al.
Publicado: (2015)

Role of Molecular Recognition in l-Cystine Crystal Growth Inhibition
por: Poloni, Laura N., et al.
Publicado: (2017)

Gold nanoparticles capped with L-glycine, L-cystine, and L-tyrosine: toxicity profiling and antioxidant potential
por: Ditta, Sarwar Allah, et al.
Publicado: (2023)

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
por: Dixon, Scott J, et al.
Publicado: (2014)

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter
por: Bentea, Eduard, et al.
Publicado: (2020)

Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment
por: Hung, Chung-Chieh, et al.
Publicado: (2021)

Molecular basis for redox control by the human cystine/glutamate antiporter system xc(−)
por: Parker, Joanne L., et al.
Publicado: (2021)

Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice
por: Martis, Renita Maria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3ajp47gj5a2j6sb2ahmcffaa9a