In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model

BACKGROUND: MazF is an endoribonuclease encoded by Escherichia coli that specifically cleaves the ACA sequence of mRNA. In our previous report, conditional expression of MazF in the HIV-1 LTR rendered CD4+ T lymphocytes resistant to HIV-1 replication. In this study, we examined the in vivo safety an...

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Detalles Bibliográficos
Autores principales: Chono, Hideto, Saito, Naoki, Tsuda, Hiroshi, Shibata, Hiroaki, Ageyama, Naohide, Terao, Keiji, Yasutomi, Yasuhiro, Mineno, Junichi, Kato, Ikunoshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157387/
https://www.ncbi.nlm.nih.gov/pubmed/21858176
http://dx.doi.org/10.1371/journal.pone.0023585

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