Fluorescence Dequenching Makes Haem-Free Soluble Guanylate Cyclase Detectable in Living Cells

In cardiovascular disease, the protective NO/sGC/cGMP signalling-pathway is impaired due to a decreased pool of NO-sensitive haem-containing sGC accompanied by a reciprocal increase in NO-insensitive haem-free sGC. However, no direct method to detect cellular haem-free sGC other than its activation...

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Detalles Bibliográficos
Autores principales: Hoffmann, Linda S., Schmidt, Peter M., Keim, Yvonne, Hoffmann, Carsten, Schmidt, Harald H. H. W., Stasch, Johannes-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157391/
https://www.ncbi.nlm.nih.gov/pubmed/21858179
http://dx.doi.org/10.1371/journal.pone.0023596

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