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Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...

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Detalles Bibliográficos
Autores principales:	Jiang, Zhihua, Kamath, Ravindra, Jin, Shunquian, Balasubramani, Manimalha, Pandita, Tej K, Rajasekaran, Baskaran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157453/ https://www.ncbi.nlm.nih.gov/pubmed/21781306 http://dx.doi.org/10.1186/1476-4598-10-88

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