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Implicating Calpain in Tau-Mediated Toxicity In Vivo

Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in d...

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Detalles Bibliográficos
Autores principales:	Reinecke, James B., DeVos, Sarah L., McGrath, James P., Shepard, Amanda M., Goncharoff, Dustin K., Tait, Don N., Fleming, Samantha R., Vincent, Michael P., Steinhilb, Michelle L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157467/ https://www.ncbi.nlm.nih.gov/pubmed/21858230 http://dx.doi.org/10.1371/journal.pone.0023865

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