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Plasmodium falciparum Metacaspase PfMCA-1 Triggers a z-VAD-fmk Inhibitable Protease to Promote Cell Death

Activation of proteolytic cell death pathways may circumvent drug resistance in deadly protozoan parasites such as Plasmodium falciparum and Leishmania. To this end, it is important to define the cell death pathway(s) in parasites and thus characterize proteases such as metacaspases (MCA), which hav...

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Detalles Bibliográficos
Autores principales: Meslin, Benoît, Beavogui, Abdoul H., Fasel, Nicolas, Picot, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157471/
https://www.ncbi.nlm.nih.gov/pubmed/21858231
http://dx.doi.org/10.1371/journal.pone.0023867