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Disturbances of apoptotic cell clearance in systemic lupus erythematosus

Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is driven by defective clearance of dead and dying cells. In lupus patients, large numbers of apoptotic cells accumulate in vario...

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Autores principales: Shao, Wen-Hai, Cohen, Philip L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157636/
https://www.ncbi.nlm.nih.gov/pubmed/21371352
http://dx.doi.org/10.1186/ar3206
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author Shao, Wen-Hai
Cohen, Philip L
author_facet Shao, Wen-Hai
Cohen, Philip L
author_sort Shao, Wen-Hai
collection PubMed
description Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is driven by defective clearance of dead and dying cells. In lupus patients, large numbers of apoptotic cells accumulate in various tissues including germinal centers. In the present review, we discuss the danger signals released by apoptotic cells, their triggering of inflammatory responses, and the breakdown of B-cell tolerance. We also review the pathogenic role of apoptotic cell clearance in systemic lupus erythematosus.
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spelling pubmed-31576362011-08-28 Disturbances of apoptotic cell clearance in systemic lupus erythematosus Shao, Wen-Hai Cohen, Philip L Arthritis Res Ther Review Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is driven by defective clearance of dead and dying cells. In lupus patients, large numbers of apoptotic cells accumulate in various tissues including germinal centers. In the present review, we discuss the danger signals released by apoptotic cells, their triggering of inflammatory responses, and the breakdown of B-cell tolerance. We also review the pathogenic role of apoptotic cell clearance in systemic lupus erythematosus. BioMed Central 2011 2011-02-28 /pmc/articles/PMC3157636/ /pubmed/21371352 http://dx.doi.org/10.1186/ar3206 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Shao, Wen-Hai
Cohen, Philip L
Disturbances of apoptotic cell clearance in systemic lupus erythematosus
title Disturbances of apoptotic cell clearance in systemic lupus erythematosus
title_full Disturbances of apoptotic cell clearance in systemic lupus erythematosus
title_fullStr Disturbances of apoptotic cell clearance in systemic lupus erythematosus
title_full_unstemmed Disturbances of apoptotic cell clearance in systemic lupus erythematosus
title_short Disturbances of apoptotic cell clearance in systemic lupus erythematosus
title_sort disturbances of apoptotic cell clearance in systemic lupus erythematosus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157636/
https://www.ncbi.nlm.nih.gov/pubmed/21371352
http://dx.doi.org/10.1186/ar3206
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