In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations

Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune conditions characterized by necrotizing inflammation of small blood vessels. The immunogenesis and etiology of these conditions are unknown, but our knowledge of the immunopathogenesis has increased considerably in rece...

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Detalles Bibliográficos
Autores principales: Heeringa, Peter, Little, Mark A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157641/
https://www.ncbi.nlm.nih.gov/pubmed/21371348
http://dx.doi.org/10.1186/ar3236
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author Heeringa, Peter
Little, Mark A
author_facet Heeringa, Peter
Little, Mark A
author_sort Heeringa, Peter
collection PubMed
description Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune conditions characterized by necrotizing inflammation of small blood vessels. The immunogenesis and etiology of these conditions are unknown, but our knowledge of the immunopathogenesis has increased considerably in recent years. In this review, we discuss the animal models currently used to investigate the mechanisms of vascular injury and to test novel therapies. We outline their advantages and limitations and propose potential directions for future research.
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spelling pubmed-31576412011-08-28 In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations Heeringa, Peter Little, Mark A Arthritis Res Ther Review Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune conditions characterized by necrotizing inflammation of small blood vessels. The immunogenesis and etiology of these conditions are unknown, but our knowledge of the immunopathogenesis has increased considerably in recent years. In this review, we discuss the animal models currently used to investigate the mechanisms of vascular injury and to test novel therapies. We outline their advantages and limitations and propose potential directions for future research. BioMed Central 2011 2011-02-28 /pmc/articles/PMC3157641/ /pubmed/21371348 http://dx.doi.org/10.1186/ar3236 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Heeringa, Peter
Little, Mark A
In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations
title In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations
title_full In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations
title_fullStr In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations
title_full_unstemmed In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations
title_short In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations
title_sort in vivo approaches to investigate anca-associated vasculitis: lessons and limitations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157641/
https://www.ncbi.nlm.nih.gov/pubmed/21371348
http://dx.doi.org/10.1186/ar3236
work_keys_str_mv AT heeringapeter invivoapproachestoinvestigateancaassociatedvasculitislessonsandlimitations
AT littlemarka invivoapproachestoinvestigateancaassociatedvasculitislessonsandlimitations

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