Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma

A T-to-G germline single nucleotide polymorphism in the promoter region of MDM2 (SNP309) has been reported to markedly accelerate tumor formation in humans suggesting that it may represent a powerful cancer predisposing allele. Since its first description in 2004, a large number of retrospective ana...

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Autores principales: Post, Sean M., Pant, Vinod, Abbas, Hussein, Quintás-Cardama, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157715/
https://www.ncbi.nlm.nih.gov/pubmed/21301048
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author Post, Sean M.
Pant, Vinod
Abbas, Hussein
Quintás-Cardama, Alfonso
author_facet Post, Sean M.
Pant, Vinod
Abbas, Hussein
Quintás-Cardama, Alfonso
author_sort Post, Sean M.
collection PubMed
description A T-to-G germline single nucleotide polymorphism in the promoter region of MDM2 (SNP309) has been reported to markedly accelerate tumor formation in humans suggesting that it may represent a powerful cancer predisposing allele. Since its first description in 2004, a large number of retrospective analyses involving a wide variety of human malignancies have been reported, showing conflicting results regarding the impact of Mdm2(SNP309) status on cancer risk and response to cancer therapy. Here, we appraise the available information on the effect of Mdm2(SNP309) in lymphoma and leukemia and discuss the factors that likely account for the conflicting results observed in the studies reported to date.
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spelling pubmed-31577152012-01-18 Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma Post, Sean M. Pant, Vinod Abbas, Hussein Quintás-Cardama, Alfonso Oncotarget Reviews A T-to-G germline single nucleotide polymorphism in the promoter region of MDM2 (SNP309) has been reported to markedly accelerate tumor formation in humans suggesting that it may represent a powerful cancer predisposing allele. Since its first description in 2004, a large number of retrospective analyses involving a wide variety of human malignancies have been reported, showing conflicting results regarding the impact of Mdm2(SNP309) status on cancer risk and response to cancer therapy. Here, we appraise the available information on the effect of Mdm2(SNP309) in lymphoma and leukemia and discuss the factors that likely account for the conflicting results observed in the studies reported to date. Impact Journals LLC 2010-07-27 /pmc/articles/PMC3157715/ /pubmed/21301048 Text en Copyright: © 2010 Post et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Reviews
Post, Sean M.
Pant, Vinod
Abbas, Hussein
Quintás-Cardama, Alfonso
Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
title Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
title_full Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
title_fullStr Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
title_full_unstemmed Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
title_short Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
title_sort prognostic impact of the mdm2(snp309) allele in leukemia and lymphoma
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157715/
https://www.ncbi.nlm.nih.gov/pubmed/21301048
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