What are genome-wide association studies telling us about B-cell tumor development?

It has long been speculated that common genetic variation influences the development of B-cell malignancy, however until recently evidence for this assertion was lacking. The advent of genome-wide association studies (GWAS) has allowed the search for this class of susceptibility allele to be conduct...

Descripción completa

Detalles Bibliográficos
Autores principales: Sherborne, Amy L, Houlston, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157732/
https://www.ncbi.nlm.nih.gov/pubmed/21307401
_version_ 1782210329064767488
author Sherborne, Amy L
Houlston, Richard S
author_facet Sherborne, Amy L
Houlston, Richard S
author_sort Sherborne, Amy L
collection PubMed
description It has long been speculated that common genetic variation influences the development of B-cell malignancy, however until recently evidence for this assertion was lacking. The advent of genome-wide association studies (GWAS) has allowed the search for this class of susceptibility allele to be conducted on a genome-wide basis. Recent GWAS of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL) have identified novel disease genes for CLL and ALL and underscore the importance of polymorphic variation in B-cell development genes as determinants of leukemia risk.
format Online
Article
Text
id pubmed-3157732
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-31577322012-01-18 What are genome-wide association studies telling us about B-cell tumor development? Sherborne, Amy L Houlston, Richard S Oncotarget Research Perspectives It has long been speculated that common genetic variation influences the development of B-cell malignancy, however until recently evidence for this assertion was lacking. The advent of genome-wide association studies (GWAS) has allowed the search for this class of susceptibility allele to be conducted on a genome-wide basis. Recent GWAS of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL) have identified novel disease genes for CLL and ALL and underscore the importance of polymorphic variation in B-cell development genes as determinants of leukemia risk. Impact Journals LLC 2010-09-11 /pmc/articles/PMC3157732/ /pubmed/21307401 Text en Copyright: © 2010 Sherborne and Houlston http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Sherborne, Amy L
Houlston, Richard S
What are genome-wide association studies telling us about B-cell tumor development?
title What are genome-wide association studies telling us about B-cell tumor development?
title_full What are genome-wide association studies telling us about B-cell tumor development?
title_fullStr What are genome-wide association studies telling us about B-cell tumor development?
title_full_unstemmed What are genome-wide association studies telling us about B-cell tumor development?
title_short What are genome-wide association studies telling us about B-cell tumor development?
title_sort what are genome-wide association studies telling us about b-cell tumor development?
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157732/
https://www.ncbi.nlm.nih.gov/pubmed/21307401
work_keys_str_mv AT sherborneamyl whataregenomewideassociationstudiestellingusaboutbcelltumordevelopment
AT houlstonrichards whataregenomewideassociationstudiestellingusaboutbcelltumordevelopment

Ejemplares similares