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Management and Outcome in 32 Neonates with Thrombotic Events
Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic e...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157757/ https://www.ncbi.nlm.nih.gov/pubmed/21876707 http://dx.doi.org/10.1155/2011/217564 |
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author | van Elteren, H. A. Veldt, H. S. te Pas, A. B. Roest, A. A. W. Smiers, F. J. Kollen, W. J. Sramek, A. Walther, F. J. Lopriore, E. |
author_facet | van Elteren, H. A. Veldt, H. S. te Pas, A. B. Roest, A. A. W. Smiers, F. J. Kollen, W. J. Sramek, A. Walther, F. J. Lopriore, E. |
author_sort | van Elteren, H. A. |
collection | PubMed |
description | Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage (n = 2) and abscess at the injection site (n = 1). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis. |
format | Online Article Text |
id | pubmed-3157757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31577572011-08-29 Management and Outcome in 32 Neonates with Thrombotic Events van Elteren, H. A. Veldt, H. S. te Pas, A. B. Roest, A. A. W. Smiers, F. J. Kollen, W. J. Sramek, A. Walther, F. J. Lopriore, E. Int J Pediatr Research Article Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage (n = 2) and abscess at the injection site (n = 1). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis. Hindawi Publishing Corporation 2011 2011-08-11 /pmc/articles/PMC3157757/ /pubmed/21876707 http://dx.doi.org/10.1155/2011/217564 Text en Copyright © 2011 H. A. van Elteren et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article van Elteren, H. A. Veldt, H. S. te Pas, A. B. Roest, A. A. W. Smiers, F. J. Kollen, W. J. Sramek, A. Walther, F. J. Lopriore, E. Management and Outcome in 32 Neonates with Thrombotic Events |
title | Management and Outcome in 32 Neonates with Thrombotic Events |
title_full | Management and Outcome in 32 Neonates with Thrombotic Events |
title_fullStr | Management and Outcome in 32 Neonates with Thrombotic Events |
title_full_unstemmed | Management and Outcome in 32 Neonates with Thrombotic Events |
title_short | Management and Outcome in 32 Neonates with Thrombotic Events |
title_sort | management and outcome in 32 neonates with thrombotic events |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157757/ https://www.ncbi.nlm.nih.gov/pubmed/21876707 http://dx.doi.org/10.1155/2011/217564 |
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