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Adhesion molecules in different treatments of acute myocardial infarction

BACKGROUND: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to determine the time course of soluble adhesion molecules in patients with acute myocardial infarction after attempted reperfusion by thr...

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Autores principales: Kerner, Thoralf, Ahlers, Olaf, Reschreiter, Henrik, Bührer, Christoph, Möckel, Martin, Gerlach, Herwig
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31578/
https://www.ncbi.nlm.nih.gov/pubmed/11353931
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author Kerner, Thoralf
Ahlers, Olaf
Reschreiter, Henrik
Bührer, Christoph
Möckel, Martin
Gerlach, Herwig
author_facet Kerner, Thoralf
Ahlers, Olaf
Reschreiter, Henrik
Bührer, Christoph
Möckel, Martin
Gerlach, Herwig
author_sort Kerner, Thoralf
collection PubMed
description BACKGROUND: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to determine the time course of soluble adhesion molecules in patients with acute myocardial infarction after attempted reperfusion by thrombolysis with tissue plasminogen activator (tPA) or streptokinase (SK), or percutaneous transluminal coronary angioplasty (PTCA). METHODS: In 3 × 10 randomly selected patients with acute myocardial infarction undergoing thrombolysis with tPA or SK, or treated with PTCA, plasma concentrations of soluble L-selectin, P-selectin, E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) were measured by enzyme-linked immunosorbent assay, 30 min and 1, 2, 4, 8, 12 and 24 hours after intervention. RESULTS: After thrombolysis with tPA, soluble L-selectin concentrations were persistently depressed and soluble PECAM-1 concentrations were elevated, compared with controls, SK and PTCA. While soluble VCAM-1 concentrations did not differ within the first hours after interventions between the three groups, soluble VCAM-1 rose by 24 hours after tPA thrombolysis but did not increase after SK and PTCA treatment. Soluble ICAM-1 concentrations were consistently elevated after PTCA compared with controls and thrombolysed patients. Soluble E-selectin was depressed after tPA thrombolysis and PTCA in comparison with controls, while the SK group showed an increase throughout the observation period. Soluble P-selectin was increased after PTCA and SK lysis up to 8 hours after treatment compared with controls, but no significant differences could be found between treatment groups. CONCLUSION: Adhesion molecules mediating leukocyte endothelial interactions are altered subsequent to postischemic reperfusion and by treatment with thrombolytic agents and angioplasty. The clinical relevance of these biological changes remains to be determined.
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spelling pubmed-315782001-05-18 Adhesion molecules in different treatments of acute myocardial infarction Kerner, Thoralf Ahlers, Olaf Reschreiter, Henrik Bührer, Christoph Möckel, Martin Gerlach, Herwig Crit Care Primary Research BACKGROUND: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to determine the time course of soluble adhesion molecules in patients with acute myocardial infarction after attempted reperfusion by thrombolysis with tissue plasminogen activator (tPA) or streptokinase (SK), or percutaneous transluminal coronary angioplasty (PTCA). METHODS: In 3 × 10 randomly selected patients with acute myocardial infarction undergoing thrombolysis with tPA or SK, or treated with PTCA, plasma concentrations of soluble L-selectin, P-selectin, E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) were measured by enzyme-linked immunosorbent assay, 30 min and 1, 2, 4, 8, 12 and 24 hours after intervention. RESULTS: After thrombolysis with tPA, soluble L-selectin concentrations were persistently depressed and soluble PECAM-1 concentrations were elevated, compared with controls, SK and PTCA. While soluble VCAM-1 concentrations did not differ within the first hours after interventions between the three groups, soluble VCAM-1 rose by 24 hours after tPA thrombolysis but did not increase after SK and PTCA treatment. Soluble ICAM-1 concentrations were consistently elevated after PTCA compared with controls and thrombolysed patients. Soluble E-selectin was depressed after tPA thrombolysis and PTCA in comparison with controls, while the SK group showed an increase throughout the observation period. Soluble P-selectin was increased after PTCA and SK lysis up to 8 hours after treatment compared with controls, but no significant differences could be found between treatment groups. CONCLUSION: Adhesion molecules mediating leukocyte endothelial interactions are altered subsequent to postischemic reperfusion and by treatment with thrombolytic agents and angioplasty. The clinical relevance of these biological changes remains to be determined. BioMed Central 2001 2001-04-06 /pmc/articles/PMC31578/ /pubmed/11353931 Text en Copyright © 2001 Kerner et al, licensee BioMed Central Ltd
spellingShingle Primary Research
Kerner, Thoralf
Ahlers, Olaf
Reschreiter, Henrik
Bührer, Christoph
Möckel, Martin
Gerlach, Herwig
Adhesion molecules in different treatments of acute myocardial infarction
title Adhesion molecules in different treatments of acute myocardial infarction
title_full Adhesion molecules in different treatments of acute myocardial infarction
title_fullStr Adhesion molecules in different treatments of acute myocardial infarction
title_full_unstemmed Adhesion molecules in different treatments of acute myocardial infarction
title_short Adhesion molecules in different treatments of acute myocardial infarction
title_sort adhesion molecules in different treatments of acute myocardial infarction
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31578/
https://www.ncbi.nlm.nih.gov/pubmed/11353931
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