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Evolutionary Accessibility of Mutational Pathways

Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. For the trait under evolutionary selection (‘fitness’), measured values over all possible combinations of a set of mutations yield a fitness landscape that determines which mutational states...

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Detalles Bibliográficos
Autores principales: Franke, Jasper, Klözer, Alexander, de Visser, J. Arjan G. M., Krug, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158036/
https://www.ncbi.nlm.nih.gov/pubmed/21876664
http://dx.doi.org/10.1371/journal.pcbi.1002134