CODA-RET reveals functional selectivity as a result of GPCR heteromerization

Here we present a novel method that combines protein complementation with resonance energy transfer to study conformational changes in response to activation of a defined G protein-coupled receptor heteromer, and we apply the approach to the putative dopamine D1-D2 receptor heteromer. Remarkably, th...

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Detalles Bibliográficos
Autores principales: Urizar, Eneko, Yano, Hideaki, Kolster, Rachel, Galés, Céline, Lambert, Nevin, Javitch, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158273/
https://www.ncbi.nlm.nih.gov/pubmed/21785426
http://dx.doi.org/10.1038/nchembio.623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158273/
https://www.ncbi.nlm.nih.gov/pubmed/21785426
http://dx.doi.org/10.1038/nchembio.623

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