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CODA-RET reveals functional selectivity as a result of GPCR heteromerization

Here we present a novel method that combines protein complementation with resonance energy transfer to study conformational changes in response to activation of a defined G protein-coupled receptor heteromer, and we apply the approach to the putative dopamine D1-D2 receptor heteromer. Remarkably, th...

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Detalles Bibliográficos
Autores principales:	Urizar, Eneko, Yano, Hideaki, Kolster, Rachel, Galés, Céline, Lambert, Nevin, Javitch, Jonathan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158273/ https://www.ncbi.nlm.nih.gov/pubmed/21785426 http://dx.doi.org/10.1038/nchembio.623

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