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Cell motility: the integrating role of the plasma membrane
The plasma membrane is of central importance in the motility process. It defines the boundary separating the intracellular and extracellular environments, and mediates the interactions between a motile cell and its environment. Furthermore, the membrane serves as a dynamic platform for localization...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158336/ https://www.ncbi.nlm.nih.gov/pubmed/21833780 http://dx.doi.org/10.1007/s00249-011-0741-0 |
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author | Keren, Kinneret |
author_facet | Keren, Kinneret |
author_sort | Keren, Kinneret |
collection | PubMed |
description | The plasma membrane is of central importance in the motility process. It defines the boundary separating the intracellular and extracellular environments, and mediates the interactions between a motile cell and its environment. Furthermore, the membrane serves as a dynamic platform for localization of various components which actively participate in all aspects of the motility process, including force generation, adhesion, signaling, and regulation. Membrane transport between internal membranes and the plasma membrane, and in particular polarized membrane transport, facilitates continuous reorganization of the plasma membrane and is thought to be involved in maintaining polarity and recycling of essential components in some motile cell types. Beyond its biochemical composition, the mechanical characteristics of the plasma membrane and, in particular, membrane tension are of central importance in cell motility; membrane tension affects the rates of all the processes which involve membrane deformation including edge extension, endocytosis, and exocytosis. Most importantly, the mechanical characteristics of the membrane and its biochemical composition are tightly intertwined; membrane tension and local curvature are largely determined by the biochemical composition of the membrane and the biochemical reactions taking place; at the same time, curvature and tension affect the localization of components and reaction rates. This review focuses on this dynamic interplay and the feedbacks between the biochemical and biophysical characteristics of the membrane and their effects on cell movement. New insight on these will be crucial for understanding the motility process. |
format | Online Article Text |
id | pubmed-3158336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-31583362011-09-21 Cell motility: the integrating role of the plasma membrane Keren, Kinneret Eur Biophys J Review The plasma membrane is of central importance in the motility process. It defines the boundary separating the intracellular and extracellular environments, and mediates the interactions between a motile cell and its environment. Furthermore, the membrane serves as a dynamic platform for localization of various components which actively participate in all aspects of the motility process, including force generation, adhesion, signaling, and regulation. Membrane transport between internal membranes and the plasma membrane, and in particular polarized membrane transport, facilitates continuous reorganization of the plasma membrane and is thought to be involved in maintaining polarity and recycling of essential components in some motile cell types. Beyond its biochemical composition, the mechanical characteristics of the plasma membrane and, in particular, membrane tension are of central importance in cell motility; membrane tension affects the rates of all the processes which involve membrane deformation including edge extension, endocytosis, and exocytosis. Most importantly, the mechanical characteristics of the membrane and its biochemical composition are tightly intertwined; membrane tension and local curvature are largely determined by the biochemical composition of the membrane and the biochemical reactions taking place; at the same time, curvature and tension affect the localization of components and reaction rates. This review focuses on this dynamic interplay and the feedbacks between the biochemical and biophysical characteristics of the membrane and their effects on cell movement. New insight on these will be crucial for understanding the motility process. Springer-Verlag 2011-08-11 2011 /pmc/articles/PMC3158336/ /pubmed/21833780 http://dx.doi.org/10.1007/s00249-011-0741-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Keren, Kinneret Cell motility: the integrating role of the plasma membrane |
title | Cell motility: the integrating role of the plasma membrane |
title_full | Cell motility: the integrating role of the plasma membrane |
title_fullStr | Cell motility: the integrating role of the plasma membrane |
title_full_unstemmed | Cell motility: the integrating role of the plasma membrane |
title_short | Cell motility: the integrating role of the plasma membrane |
title_sort | cell motility: the integrating role of the plasma membrane |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158336/ https://www.ncbi.nlm.nih.gov/pubmed/21833780 http://dx.doi.org/10.1007/s00249-011-0741-0 |
work_keys_str_mv | AT kerenkinneret cellmotilitytheintegratingroleoftheplasmamembrane |