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Differences Between Early and Late Onset Adult Depression
BACKGROUND: It is unclear, whether age-of-onset identifies subgroups of depression. AIM: To assess the clinical presentation of depression with onset in the early adult age (18-30 years) as compared to depression with later onset (31-70 years). METHOD: A total number of 301 patients with first episo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158434/ https://www.ncbi.nlm.nih.gov/pubmed/21866230 http://dx.doi.org/10.2174/1745017901107010140 |
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author | Bukh, Jens Drachmann Bock, Camilla Vinberg, Maj Gether, Ulrik Kessing, Lars Vedel |
author_facet | Bukh, Jens Drachmann Bock, Camilla Vinberg, Maj Gether, Ulrik Kessing, Lars Vedel |
author_sort | Bukh, Jens Drachmann |
collection | PubMed |
description | BACKGROUND: It is unclear, whether age-of-onset identifies subgroups of depression. AIM: To assess the clinical presentation of depression with onset in the early adult age (18-30 years) as compared to depression with later onset (31-70 years). METHOD: A total number of 301 patients with first episode depression were systematically recruited. Characteristics including psychiatric co-morbidity, personality disorders and traits, stressful life events prior to onset, family history, and treatment outcome were assessed by structured interviews and compared by chi-square tests for categorical data, t-tests for continuous parametric data and Mann-Whitney U-test for continuous nonparametric data. Logistic and multiple regression analyses were used to adjust the analyses for potentially confounding variables. RESULTS: Patients with early onset of depression were characterised by a higher prevalence of co-morbid personality disorders, higher levels of neuroticism, and a lower prevalence of stressful life events preceding onset compared to patients with later age-of-onset. There were no differences in severity of the depressive episode, treatment outcome or family loading of psychiatric illness. CONCLUSION: Early adult onset of depression is associated with co-morbid personality deviances, whereas late onset is associated with environmental risk factors. |
format | Online Article Text |
id | pubmed-3158434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-31584342011-08-24 Differences Between Early and Late Onset Adult Depression Bukh, Jens Drachmann Bock, Camilla Vinberg, Maj Gether, Ulrik Kessing, Lars Vedel Clin Pract Epidemiol Ment Health Article BACKGROUND: It is unclear, whether age-of-onset identifies subgroups of depression. AIM: To assess the clinical presentation of depression with onset in the early adult age (18-30 years) as compared to depression with later onset (31-70 years). METHOD: A total number of 301 patients with first episode depression were systematically recruited. Characteristics including psychiatric co-morbidity, personality disorders and traits, stressful life events prior to onset, family history, and treatment outcome were assessed by structured interviews and compared by chi-square tests for categorical data, t-tests for continuous parametric data and Mann-Whitney U-test for continuous nonparametric data. Logistic and multiple regression analyses were used to adjust the analyses for potentially confounding variables. RESULTS: Patients with early onset of depression were characterised by a higher prevalence of co-morbid personality disorders, higher levels of neuroticism, and a lower prevalence of stressful life events preceding onset compared to patients with later age-of-onset. There were no differences in severity of the depressive episode, treatment outcome or family loading of psychiatric illness. CONCLUSION: Early adult onset of depression is associated with co-morbid personality deviances, whereas late onset is associated with environmental risk factors. Bentham Open 2011-08-10 /pmc/articles/PMC3158434/ /pubmed/21866230 http://dx.doi.org/10.2174/1745017901107010140 Text en © Bukh et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Bukh, Jens Drachmann Bock, Camilla Vinberg, Maj Gether, Ulrik Kessing, Lars Vedel Differences Between Early and Late Onset Adult Depression |
title | Differences Between Early and Late Onset Adult Depression |
title_full | Differences Between Early and Late Onset Adult Depression |
title_fullStr | Differences Between Early and Late Onset Adult Depression |
title_full_unstemmed | Differences Between Early and Late Onset Adult Depression |
title_short | Differences Between Early and Late Onset Adult Depression |
title_sort | differences between early and late onset adult depression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158434/ https://www.ncbi.nlm.nih.gov/pubmed/21866230 http://dx.doi.org/10.2174/1745017901107010140 |
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