Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa

BACKGROUND: Retinitis pigmentosa (RP) is an inherited eye disease characterized by the progressive degeneration of rod photoreceptor cells. Mutations in pre-mRNA splicing factors including PRPF31 have been identified as cause for RP, raising the question how mutations in general factors lead to tiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Jun, Brocher, Jan, Fischer, Utz, Winkler, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158551/
https://www.ncbi.nlm.nih.gov/pubmed/21801444
http://dx.doi.org/10.1186/1750-1326-6-56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158551/
https://www.ncbi.nlm.nih.gov/pubmed/21801444
http://dx.doi.org/10.1186/1750-1326-6-56

Ejemplares similares