Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove

Small heat shock proteins form large cytosolic assemblies from an “α-crystallin domain” (ACD) flanked by sequence extensions. Mutation of a conserved arginine in the ACD of several human small heat shock protein family members causes many common inherited diseases of the lens and neuromuscular syste...

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Detalles Bibliográficos
Autores principales: Clark, A.R., Naylor, C.E., Bagnéris, C., Keep, N.H., Slingsby, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158665/
https://www.ncbi.nlm.nih.gov/pubmed/21329698
http://dx.doi.org/10.1016/j.jmb.2011.02.020

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