Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

PknB is an essential serine/threonine kinase of Mycobacterium tuberculosis with possible roles in a number of signalling pathways involved in cell division and metabolism. We screened a library of >50,000 compounds for inhibitors of the in vitro phosphorylation of GarA (Rv1827) by PknB and identi...

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Detalles Bibliográficos
Autores principales: Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Whalley, David, Chapman, Tim, Bouloc, Nathalie, Chugh, Jasveen, Nott, Timothy J., Patel, Dony, Spivey, Vicky L., Kettleborough, Catherine A., Bryans, Justin S., Taylor, Debra L., Smerdon, Stephen J., Buxton, Roger S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Churchill Livingstone 2011
Materias:
Drug Discovery and Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158675/
https://www.ncbi.nlm.nih.gov/pubmed/21482481
http://dx.doi.org/10.1016/j.tube.2011.03.005

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