Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State

A surprising portion of both mammalian and Drosophila genomes are transcriptionally paused, undergoing initiation without elongation. We tested the hypothesis that transcriptional pausing is an obligate transition state between definitive activation and silencing as human embryonic stem cells (hESCs...

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Detalles Bibliográficos
Autores principales: Golob, Jonathan L., Kumar, Roshan M., Guenther, Matthew G., Pabon, Lil M., Pratt, Gabriel A., Loring, Jeanne F., Laurent, Louise C., Young, Richard A., Murry, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158746/
https://www.ncbi.nlm.nih.gov/pubmed/21886766
http://dx.doi.org/10.1371/journal.pone.0022416

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