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Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease

BACKGROUND: Soluble endoglin, a TGF-β receptor, plays a key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated in CKD or underlie the high risk of cardiovascular death associated with chronic kidney disease (CKD) is unknown. METHODS: Individuals wi...

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Autores principales: Charytan, David M., Helfand, Alexander M., MacDonald, Brian A., Cinelli, Angeles, Kalluri, Raghu, Zeisberg, Elisabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158786/
https://www.ncbi.nlm.nih.gov/pubmed/21886815
http://dx.doi.org/10.1371/journal.pone.0023718
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author Charytan, David M.
Helfand, Alexander M.
MacDonald, Brian A.
Cinelli, Angeles
Kalluri, Raghu
Zeisberg, Elisabeth M.
author_facet Charytan, David M.
Helfand, Alexander M.
MacDonald, Brian A.
Cinelli, Angeles
Kalluri, Raghu
Zeisberg, Elisabeth M.
author_sort Charytan, David M.
collection PubMed
description BACKGROUND: Soluble endoglin, a TGF-β receptor, plays a key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated in CKD or underlie the high risk of cardiovascular death associated with chronic kidney disease (CKD) is unknown. METHODS: Individuals with and without CKD were recruited at a single center. Estimated glomerular filtration rate (eGFR) was estimated using the modified MDRD study equation and the serum creatinine at the time of recruitment, and patients were assigned to specific CKD stage according to usual guidelines. Serum endoglin concentration was measured by ELISA and univariate and multivariable regression was used to analyze the association between eGFR or CKD stage and the concentration of soluble endoglin. RESULTS: Serum endoglin was measured in 216 patients including 118 with stage 3 or higher CKD and 9 individuals with end stage renal disease (ESRD). Serum endoglin concentration did not vary significantly with CKD stage (increase of 0.16 ng/mL per 1 stage increase in CKD, P = 0.09) or eGFR (decrease -0.06 ng/mL per 10 mL/min/1.73 m(2) increase in GFR, P = 0.12), and was not higher in individuals with ESRD than in individuals with preserved renal function (4.2±1.1 and 4.3±1.2 ng/mL, respectively). Endoglin concentration was also not significantly associated with urinary albumin excretion. CONCLUSIONS: Renal function is not associated with the circulating concentration of soluble endoglin. Elevations in soluble endoglin concentration are unlikely to contribute to the progression of CKD or the predisposition of individuals with CKD to develop cardiovascular disease.
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spelling pubmed-31587862011-08-30 Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease Charytan, David M. Helfand, Alexander M. MacDonald, Brian A. Cinelli, Angeles Kalluri, Raghu Zeisberg, Elisabeth M. PLoS One Research Article BACKGROUND: Soluble endoglin, a TGF-β receptor, plays a key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated in CKD or underlie the high risk of cardiovascular death associated with chronic kidney disease (CKD) is unknown. METHODS: Individuals with and without CKD were recruited at a single center. Estimated glomerular filtration rate (eGFR) was estimated using the modified MDRD study equation and the serum creatinine at the time of recruitment, and patients were assigned to specific CKD stage according to usual guidelines. Serum endoglin concentration was measured by ELISA and univariate and multivariable regression was used to analyze the association between eGFR or CKD stage and the concentration of soluble endoglin. RESULTS: Serum endoglin was measured in 216 patients including 118 with stage 3 or higher CKD and 9 individuals with end stage renal disease (ESRD). Serum endoglin concentration did not vary significantly with CKD stage (increase of 0.16 ng/mL per 1 stage increase in CKD, P = 0.09) or eGFR (decrease -0.06 ng/mL per 10 mL/min/1.73 m(2) increase in GFR, P = 0.12), and was not higher in individuals with ESRD than in individuals with preserved renal function (4.2±1.1 and 4.3±1.2 ng/mL, respectively). Endoglin concentration was also not significantly associated with urinary albumin excretion. CONCLUSIONS: Renal function is not associated with the circulating concentration of soluble endoglin. Elevations in soluble endoglin concentration are unlikely to contribute to the progression of CKD or the predisposition of individuals with CKD to develop cardiovascular disease. Public Library of Science 2011-08-19 /pmc/articles/PMC3158786/ /pubmed/21886815 http://dx.doi.org/10.1371/journal.pone.0023718 Text en Charytan et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Charytan, David M.
Helfand, Alexander M.
MacDonald, Brian A.
Cinelli, Angeles
Kalluri, Raghu
Zeisberg, Elisabeth M.
Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease
title Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease
title_full Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease
title_fullStr Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease
title_full_unstemmed Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease
title_short Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease
title_sort circulating endoglin concentration is not elevated in chronic kidney disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158786/
https://www.ncbi.nlm.nih.gov/pubmed/21886815
http://dx.doi.org/10.1371/journal.pone.0023718
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