A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome

Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the ‘prot...

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Detalles Bibliográficos
Autores principales: Krupkin, Miri, Matzov, Donna, Tang, Hua, Metz, Markus, Kalaora, Rinat, Belousoff, Matthew J., Zimmerman, Ella, Bashan, Anat, Yonath, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158926/
https://www.ncbi.nlm.nih.gov/pubmed/21930590
http://dx.doi.org/10.1098/rstb.2011.0146
Descripción
Sumario:Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the ‘proto-ribosome’. This ‘proto-ribosome’ could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the ‘pre-proto-ribosome’, which was adapted for producing proteins.

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