A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome

Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the ‘prot...

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Autores principales: Krupkin, Miri, Matzov, Donna, Tang, Hua, Metz, Markus, Kalaora, Rinat, Belousoff, Matthew J., Zimmerman, Ella, Bashan, Anat, Yonath, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158926/
https://www.ncbi.nlm.nih.gov/pubmed/21930590
http://dx.doi.org/10.1098/rstb.2011.0146
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author Krupkin, Miri
Matzov, Donna
Tang, Hua
Metz, Markus
Kalaora, Rinat
Belousoff, Matthew J.
Zimmerman, Ella
Bashan, Anat
Yonath, Ada
author_facet Krupkin, Miri
Matzov, Donna
Tang, Hua
Metz, Markus
Kalaora, Rinat
Belousoff, Matthew J.
Zimmerman, Ella
Bashan, Anat
Yonath, Ada
author_sort Krupkin, Miri
collection PubMed
description Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the ‘proto-ribosome’. This ‘proto-ribosome’ could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the ‘pre-proto-ribosome’, which was adapted for producing proteins.
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spelling pubmed-31589262011-10-27 A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome Krupkin, Miri Matzov, Donna Tang, Hua Metz, Markus Kalaora, Rinat Belousoff, Matthew J. Zimmerman, Ella Bashan, Anat Yonath, Ada Philos Trans R Soc Lond B Biol Sci Articles Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the ‘proto-ribosome’. This ‘proto-ribosome’ could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the ‘pre-proto-ribosome’, which was adapted for producing proteins. The Royal Society 2011-10-27 /pmc/articles/PMC3158926/ /pubmed/21930590 http://dx.doi.org/10.1098/rstb.2011.0146 Text en This journal is © 2011 The Royal Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Krupkin, Miri
Matzov, Donna
Tang, Hua
Metz, Markus
Kalaora, Rinat
Belousoff, Matthew J.
Zimmerman, Ella
Bashan, Anat
Yonath, Ada
A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
title A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
title_full A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
title_fullStr A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
title_full_unstemmed A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
title_short A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
title_sort vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158926/
https://www.ncbi.nlm.nih.gov/pubmed/21930590
http://dx.doi.org/10.1098/rstb.2011.0146
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