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Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal dementia/Pick Complex or Alzheimer’s disease, is a heterogeneous clinical condition characterized by a progressive loss of specific language functions with initial sparing of other cognitiv...

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Detalles Bibliográficos
Autores principales: Harciarek, Michał, Kertesz, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158975/
https://www.ncbi.nlm.nih.gov/pubmed/21809067
http://dx.doi.org/10.1007/s11065-011-9175-9
Descripción
Sumario:Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal dementia/Pick Complex or Alzheimer’s disease, is a heterogeneous clinical condition characterized by a progressive loss of specific language functions with initial sparing of other cognitive domains. Based on the constellation of symptoms, PPA has been classified into a nonfluent, semantic, or logopenic variant. This review of the literature aims to characterize the speech and language impairment, cognition, neuroimaging, pathology, genetics, and epidemiology associated with each of these variants. Some therapeutic recommendations, theoretical implications, and directions for future research have been also provided.