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Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal dementia/Pick Complex or Alzheimer’s disease, is a heterogeneous clinical condition characterized by a progressive loss of specific language functions with initial sparing of other cognitiv...

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Detalles Bibliográficos
Autores principales: Harciarek, Michał, Kertesz, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158975/
https://www.ncbi.nlm.nih.gov/pubmed/21809067
http://dx.doi.org/10.1007/s11065-011-9175-9
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author Harciarek, Michał
Kertesz, Andrew
author_facet Harciarek, Michał
Kertesz, Andrew
author_sort Harciarek, Michał
collection PubMed
description Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal dementia/Pick Complex or Alzheimer’s disease, is a heterogeneous clinical condition characterized by a progressive loss of specific language functions with initial sparing of other cognitive domains. Based on the constellation of symptoms, PPA has been classified into a nonfluent, semantic, or logopenic variant. This review of the literature aims to characterize the speech and language impairment, cognition, neuroimaging, pathology, genetics, and epidemiology associated with each of these variants. Some therapeutic recommendations, theoretical implications, and directions for future research have been also provided.
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spelling pubmed-31589752011-09-21 Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship Harciarek, Michał Kertesz, Andrew Neuropsychol Rev Review Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal dementia/Pick Complex or Alzheimer’s disease, is a heterogeneous clinical condition characterized by a progressive loss of specific language functions with initial sparing of other cognitive domains. Based on the constellation of symptoms, PPA has been classified into a nonfluent, semantic, or logopenic variant. This review of the literature aims to characterize the speech and language impairment, cognition, neuroimaging, pathology, genetics, and epidemiology associated with each of these variants. Some therapeutic recommendations, theoretical implications, and directions for future research have been also provided. Springer US 2011-08-02 2011 /pmc/articles/PMC3158975/ /pubmed/21809067 http://dx.doi.org/10.1007/s11065-011-9175-9 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Harciarek, Michał
Kertesz, Andrew
Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship
title Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship
title_full Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship
title_fullStr Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship
title_full_unstemmed Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship
title_short Primary Progressive Aphasias and Their Contribution to the Contemporary Knowledge About the Brain-Language Relationship
title_sort primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158975/
https://www.ncbi.nlm.nih.gov/pubmed/21809067
http://dx.doi.org/10.1007/s11065-011-9175-9
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