Cargando…
Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice
Insulin/insulin-like growth factor type 1 signaling regulates lifespan and resistance to oxidative stress in worms, flies, and mammals. In a previous study, we revealed that insulin receptor (IR) mutant mice, which carry a homologous mutation found in the long-lived daf-2 mutant of Caenorhabditis el...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159008/ https://www.ncbi.nlm.nih.gov/pubmed/21876806 http://dx.doi.org/10.4061/2011/315640 |
_version_ | 1782210407678607360 |
---|---|
author | Shimizu, Takahiko Baba, Tomonori Ogawara, Midori Shirasawa, Takuji |
author_facet | Shimizu, Takahiko Baba, Tomonori Ogawara, Midori Shirasawa, Takuji |
author_sort | Shimizu, Takahiko |
collection | PubMed |
description | Insulin/insulin-like growth factor type 1 signaling regulates lifespan and resistance to oxidative stress in worms, flies, and mammals. In a previous study, we revealed that insulin receptor (IR) mutant mice, which carry a homologous mutation found in the long-lived daf-2 mutant of Caenorhabditis elegans, showed enhanced resistance to oxidative stress cooperatively modulated by sex hormones and dietary signals (Baba et al., (2005)). We herein investigated the lifespan of IR mutant mice to evaluate the biological significance of insulin signaling in mice. Under normoxia, mutant male mice had a lifespan comparable to that of wild-type male mice. IR mutant female mice also showed a lifespan similar to that of wild-type female mice, in spite of the fact that the IR mutant female mice acquired more resistance to oxidative stress than IR mutant male mice. On the other hand, IR mutant male and female mice both showed insulin resistance with hyperinsulinemia, but they did not develop hyperglycemia throughout their entire lifespan. These data indicate that the IR mutation does not impact the lifespan in mice, thus suggesting that insulin signaling might have a limited effect on the lifespan of mice. |
format | Online Article Text |
id | pubmed-3159008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31590082011-08-29 Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice Shimizu, Takahiko Baba, Tomonori Ogawara, Midori Shirasawa, Takuji J Aging Res Research Article Insulin/insulin-like growth factor type 1 signaling regulates lifespan and resistance to oxidative stress in worms, flies, and mammals. In a previous study, we revealed that insulin receptor (IR) mutant mice, which carry a homologous mutation found in the long-lived daf-2 mutant of Caenorhabditis elegans, showed enhanced resistance to oxidative stress cooperatively modulated by sex hormones and dietary signals (Baba et al., (2005)). We herein investigated the lifespan of IR mutant mice to evaluate the biological significance of insulin signaling in mice. Under normoxia, mutant male mice had a lifespan comparable to that of wild-type male mice. IR mutant female mice also showed a lifespan similar to that of wild-type female mice, in spite of the fact that the IR mutant female mice acquired more resistance to oxidative stress than IR mutant male mice. On the other hand, IR mutant male and female mice both showed insulin resistance with hyperinsulinemia, but they did not develop hyperglycemia throughout their entire lifespan. These data indicate that the IR mutation does not impact the lifespan in mice, thus suggesting that insulin signaling might have a limited effect on the lifespan of mice. SAGE-Hindawi Access to Research 2011 2011-08-18 /pmc/articles/PMC3159008/ /pubmed/21876806 http://dx.doi.org/10.4061/2011/315640 Text en Copyright © 2011 Takahiko Shimizu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shimizu, Takahiko Baba, Tomonori Ogawara, Midori Shirasawa, Takuji Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice |
title | Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice |
title_full | Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice |
title_fullStr | Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice |
title_full_unstemmed | Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice |
title_short | Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice |
title_sort | lifespan and glucose metabolism in insulin receptor mutant mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159008/ https://www.ncbi.nlm.nih.gov/pubmed/21876806 http://dx.doi.org/10.4061/2011/315640 |
work_keys_str_mv | AT shimizutakahiko lifespanandglucosemetabolismininsulinreceptormutantmice AT babatomonori lifespanandglucosemetabolismininsulinreceptormutantmice AT ogawaramidori lifespanandglucosemetabolismininsulinreceptormutantmice AT shirasawatakuji lifespanandglucosemetabolismininsulinreceptormutantmice |