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Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders

A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic i...

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Autor principal: Rossignol, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159129/
https://www.ncbi.nlm.nih.gov/pubmed/21876820
http://dx.doi.org/10.1155/2011/649325
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author Rossignol, E.
author_facet Rossignol, E.
author_sort Rossignol, E.
collection PubMed
description A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders.
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spelling pubmed-31591292011-08-29 Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders Rossignol, E. Neural Plast Review Article A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders. Hindawi Publishing Corporation 2011 2011-08-18 /pmc/articles/PMC3159129/ /pubmed/21876820 http://dx.doi.org/10.1155/2011/649325 Text en Copyright © 2011 E. Rossignol. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rossignol, E.
Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
title Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
title_full Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
title_fullStr Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
title_full_unstemmed Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
title_short Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
title_sort genetics and function of neocortical gabaergic interneurons in neurodevelopmental disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159129/
https://www.ncbi.nlm.nih.gov/pubmed/21876820
http://dx.doi.org/10.1155/2011/649325
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