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Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159129/ https://www.ncbi.nlm.nih.gov/pubmed/21876820 http://dx.doi.org/10.1155/2011/649325 |
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author | Rossignol, E. |
author_facet | Rossignol, E. |
author_sort | Rossignol, E. |
collection | PubMed |
description | A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders. |
format | Online Article Text |
id | pubmed-3159129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31591292011-08-29 Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders Rossignol, E. Neural Plast Review Article A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders. Hindawi Publishing Corporation 2011 2011-08-18 /pmc/articles/PMC3159129/ /pubmed/21876820 http://dx.doi.org/10.1155/2011/649325 Text en Copyright © 2011 E. Rossignol. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rossignol, E. Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
title | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
title_full | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
title_fullStr | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
title_full_unstemmed | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
title_short | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
title_sort | genetics and function of neocortical gabaergic interneurons in neurodevelopmental disorders |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159129/ https://www.ncbi.nlm.nih.gov/pubmed/21876820 http://dx.doi.org/10.1155/2011/649325 |
work_keys_str_mv | AT rossignole geneticsandfunctionofneocorticalgabaergicinterneuronsinneurodevelopmentaldisorders |