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A quality index for equivalent uniform dose
Equivalent uniform dose (EUD) is the absorbed dose that, when homogeneously given to a tumor, yields the same mean surviving clonogen number as the given non-homogeneous irradiation. EUD is used as an evaluation tool under the assumption that two plans with the same value of EUD are equivalent, and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications Pvt Ltd
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159218/ https://www.ncbi.nlm.nih.gov/pubmed/21897557 http://dx.doi.org/10.4103/0971-6203.83466 |
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author | Henríquez, Francisco Cutanda Castrillón, Silvia Vargas |
author_facet | Henríquez, Francisco Cutanda Castrillón, Silvia Vargas |
author_sort | Henríquez, Francisco Cutanda |
collection | PubMed |
description | Equivalent uniform dose (EUD) is the absorbed dose that, when homogeneously given to a tumor, yields the same mean surviving clonogen number as the given non-homogeneous irradiation. EUD is used as an evaluation tool under the assumption that two plans with the same value of EUD are equivalent, and their biological effect on the tumor (clonogen survival) would be the same as the one of a homogeneous irradiation of absorbed dose EUD. In this work, this assumption has been studied, and a figure of merit of its applicability has been obtained. Distributions of surviving clonogen number for homogeneous and non-homogeneous irradiations are found to be different even if their mean values are the same, the figure of merit being greater when there is a wider difference, and the equivalence assumption being less valid. Therefore, EUD can be closer to a uniform dose for some cases than for other ones (high α values, extreme heterogeneity), and the accuracy of the radiobiological indices obtained for evaluation, could be affected. Results show that the equivalence is very sensitive to the choice of radiobiological parameters, and this conclusion has been derived from mathematical properties of EUD. |
format | Online Article Text |
id | pubmed-3159218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-31592182011-09-06 A quality index for equivalent uniform dose Henríquez, Francisco Cutanda Castrillón, Silvia Vargas J Med Phys Original Article Equivalent uniform dose (EUD) is the absorbed dose that, when homogeneously given to a tumor, yields the same mean surviving clonogen number as the given non-homogeneous irradiation. EUD is used as an evaluation tool under the assumption that two plans with the same value of EUD are equivalent, and their biological effect on the tumor (clonogen survival) would be the same as the one of a homogeneous irradiation of absorbed dose EUD. In this work, this assumption has been studied, and a figure of merit of its applicability has been obtained. Distributions of surviving clonogen number for homogeneous and non-homogeneous irradiations are found to be different even if their mean values are the same, the figure of merit being greater when there is a wider difference, and the equivalence assumption being less valid. Therefore, EUD can be closer to a uniform dose for some cases than for other ones (high α values, extreme heterogeneity), and the accuracy of the radiobiological indices obtained for evaluation, could be affected. Results show that the equivalence is very sensitive to the choice of radiobiological parameters, and this conclusion has been derived from mathematical properties of EUD. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3159218/ /pubmed/21897557 http://dx.doi.org/10.4103/0971-6203.83466 Text en © Journal of Medical Physics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Henríquez, Francisco Cutanda Castrillón, Silvia Vargas A quality index for equivalent uniform dose |
title | A quality index for equivalent uniform dose |
title_full | A quality index for equivalent uniform dose |
title_fullStr | A quality index for equivalent uniform dose |
title_full_unstemmed | A quality index for equivalent uniform dose |
title_short | A quality index for equivalent uniform dose |
title_sort | quality index for equivalent uniform dose |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159218/ https://www.ncbi.nlm.nih.gov/pubmed/21897557 http://dx.doi.org/10.4103/0971-6203.83466 |
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