Studies on the Anthelmintic Property of Aminobenzylated Mannich Bases

Studies were conducted on the anthelmintic property of about 15(e-h, 1e-1h, 2d-2f and 3e-3h) synthesized aminobenzylated Mannich bases bearing N-methyl piperazine using Indian earthworms Pheritima Posthuma against piperazine citrate as standard reference. Three concentrations of each compound (0.1,...

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Detalles Bibliográficos
Autores principales: Chaluvaraju, KC, Bhat, KI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Pharmaceutical Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159280/
https://www.ncbi.nlm.nih.gov/pubmed/21897666
http://dx.doi.org/10.4103/0975-1483.83775
Descripción
Sumario:Studies were conducted on the anthelmintic property of about 15(e-h, 1e-1h, 2d-2f and 3e-3h) synthesized aminobenzylated Mannich bases bearing N-methyl piperazine using Indian earthworms Pheritima Posthuma against piperazine citrate as standard reference. Three concentrations of each compound (0.1, 0.2, 0.3% w/v) were studied, which involved the determination of paralysis and death time of the worms. The compound 1g exhibited the most significant anthelmintic activity among all the compounds screened against the worms as compared to standard drug.

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