Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial

To evaluate the effectiveness of Uncaria tomentosa in minimizing the side effects of chemotherapy and improving the antioxidant status of colorectal cancer (CRC) patients, a randomized clinical trial was conducted. Patients (43) undergoing adjuvant/palliative chemotherapy with 5-Fluorouracil/leucovo...

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Autores principales: Farias, I. L. G., Araújo, M. C. S., Farias, J. G., Rossato, L. V., Elsenbach, L. I., Dalmora, S. L., Flores, N. M. P., Durigon, M., Cruz, I. B. M., Morsch, V. M., Schetinger, M. R. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159308/
https://www.ncbi.nlm.nih.gov/pubmed/21869902
http://dx.doi.org/10.1155/2012/892182
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author Farias, I. L. G.
Araújo, M. C. S.
Farias, J. G.
Rossato, L. V.
Elsenbach, L. I.
Dalmora, S. L.
Flores, N. M. P.
Durigon, M.
Cruz, I. B. M.
Morsch, V. M.
Schetinger, M. R. C.
author_facet Farias, I. L. G.
Araújo, M. C. S.
Farias, J. G.
Rossato, L. V.
Elsenbach, L. I.
Dalmora, S. L.
Flores, N. M. P.
Durigon, M.
Cruz, I. B. M.
Morsch, V. M.
Schetinger, M. R. C.
author_sort Farias, I. L. G.
collection PubMed
description To evaluate the effectiveness of Uncaria tomentosa in minimizing the side effects of chemotherapy and improving the antioxidant status of colorectal cancer (CRC) patients, a randomized clinical trial was conducted. Patients (43) undergoing adjuvant/palliative chemotherapy with 5-Fluorouracil/leucovorin + oxaliplatin (FOLFOX4) were split into two groups: the UT group received chemotherapy plus 300 mg of Uncaria tomentosa daily and the C group received only FOLFOX4 and served as a control. Blood samples were collected before each of the 6 cycles of chemotherapy, and hemograms, oxidative stress, enzymes antioxidants, immunologic parameters, and adverse events were analyzed. The use of 300 mg of Uncaria tomentosa daily during 6 cycles of FOLFOX4 did not change the analyzed parameters, and no toxic effects were observed.
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spelling pubmed-31593082011-08-25 Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial Farias, I. L. G. Araújo, M. C. S. Farias, J. G. Rossato, L. V. Elsenbach, L. I. Dalmora, S. L. Flores, N. M. P. Durigon, M. Cruz, I. B. M. Morsch, V. M. Schetinger, M. R. C. Evid Based Complement Alternat Med Research Article To evaluate the effectiveness of Uncaria tomentosa in minimizing the side effects of chemotherapy and improving the antioxidant status of colorectal cancer (CRC) patients, a randomized clinical trial was conducted. Patients (43) undergoing adjuvant/palliative chemotherapy with 5-Fluorouracil/leucovorin + oxaliplatin (FOLFOX4) were split into two groups: the UT group received chemotherapy plus 300 mg of Uncaria tomentosa daily and the C group received only FOLFOX4 and served as a control. Blood samples were collected before each of the 6 cycles of chemotherapy, and hemograms, oxidative stress, enzymes antioxidants, immunologic parameters, and adverse events were analyzed. The use of 300 mg of Uncaria tomentosa daily during 6 cycles of FOLFOX4 did not change the analyzed parameters, and no toxic effects were observed. Hindawi Publishing Corporation 2012 2011-08-21 /pmc/articles/PMC3159308/ /pubmed/21869902 http://dx.doi.org/10.1155/2012/892182 Text en Copyright © 2012 I. L. G. Farias et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Farias, I. L. G.
Araújo, M. C. S.
Farias, J. G.
Rossato, L. V.
Elsenbach, L. I.
Dalmora, S. L.
Flores, N. M. P.
Durigon, M.
Cruz, I. B. M.
Morsch, V. M.
Schetinger, M. R. C.
Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
title Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
title_full Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
title_fullStr Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
title_full_unstemmed Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
title_short Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
title_sort uncaria tomentosa for reducing side effects caused by chemotherapy in crc patients: clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159308/
https://www.ncbi.nlm.nih.gov/pubmed/21869902
http://dx.doi.org/10.1155/2012/892182
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