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Macular hole in Behçet's disease

OBJECTIVE: To investigate the clinical features, prevalence, role of surgical intervention and the visual prognosis of macular holes (MH) in patients with Behcet's disease (BD). MATERIALS AND METHODS: Retrospective study of patients with BD and MH from January 1998 to November 2008. RESULTS: Ou...

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Autores principales: Al-Dhibi, Hassan, Abouammoh, Marwan, Al-Harthi, Essam, Al-Gaeed, Abdulrahman, Larsson, Jorgen, Abboud, Emad, Chaudhry, Imtiaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159316/
https://www.ncbi.nlm.nih.gov/pubmed/21836340
http://dx.doi.org/10.4103/0301-4738.83611
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author Al-Dhibi, Hassan
Abouammoh, Marwan
Al-Harthi, Essam
Al-Gaeed, Abdulrahman
Larsson, Jorgen
Abboud, Emad
Chaudhry, Imtiaz
author_facet Al-Dhibi, Hassan
Abouammoh, Marwan
Al-Harthi, Essam
Al-Gaeed, Abdulrahman
Larsson, Jorgen
Abboud, Emad
Chaudhry, Imtiaz
author_sort Al-Dhibi, Hassan
collection PubMed
description OBJECTIVE: To investigate the clinical features, prevalence, role of surgical intervention and the visual prognosis of macular holes (MH) in patients with Behcet's disease (BD). MATERIALS AND METHODS: Retrospective study of patients with BD and MH from January 1998 to November 2008. RESULTS: Out of 159 patients, 21 eyes of 17 patients were identified with MH. The mean age was 38.59 (range 23-61) years and the mean follow-up period was 5.1 years (range 13-164 months). The prevalence of MH was 7%. Visual acuity (VA) at the time of presentation ranged from 20/70 to hand-motion. Optical coherence tomography (OCT) findings revealed intraretinal cysts at the edge of the MH. The mean size of MH was 983.6 um; 52% had elevated edges, 43% had flat edges and only one eye (5%) was closed postoperatively. Fluorescein angiography (FA) was consistent with macular ischemia in 76% of the cases. Human leukocyte antigen (HLA) B51 association was found in 14 of the 15 patients investigated. Six patients (out of 17) underwent pars plana vitrectomy. The final VA on their last follow-up ranged from 20/70 to 2/200. Surgical intervention for MH did not result in any visual improvement as compared to non-operated eyes. One patient lost vision completely due to elevated intraocular pressure post vitrectomy and silicon oil tamponade. CONCLUSIONS: MH in patients with BD may lead to significant visual disability. Surgical intervention does not seem to have any potential beneficial effect on the VA, probably due to significant macular ischemia and sequelae from the ocular inflammation.
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spelling pubmed-31593162011-09-07 Macular hole in Behçet's disease Al-Dhibi, Hassan Abouammoh, Marwan Al-Harthi, Essam Al-Gaeed, Abdulrahman Larsson, Jorgen Abboud, Emad Chaudhry, Imtiaz Indian J Ophthalmol Original Article OBJECTIVE: To investigate the clinical features, prevalence, role of surgical intervention and the visual prognosis of macular holes (MH) in patients with Behcet's disease (BD). MATERIALS AND METHODS: Retrospective study of patients with BD and MH from January 1998 to November 2008. RESULTS: Out of 159 patients, 21 eyes of 17 patients were identified with MH. The mean age was 38.59 (range 23-61) years and the mean follow-up period was 5.1 years (range 13-164 months). The prevalence of MH was 7%. Visual acuity (VA) at the time of presentation ranged from 20/70 to hand-motion. Optical coherence tomography (OCT) findings revealed intraretinal cysts at the edge of the MH. The mean size of MH was 983.6 um; 52% had elevated edges, 43% had flat edges and only one eye (5%) was closed postoperatively. Fluorescein angiography (FA) was consistent with macular ischemia in 76% of the cases. Human leukocyte antigen (HLA) B51 association was found in 14 of the 15 patients investigated. Six patients (out of 17) underwent pars plana vitrectomy. The final VA on their last follow-up ranged from 20/70 to 2/200. Surgical intervention for MH did not result in any visual improvement as compared to non-operated eyes. One patient lost vision completely due to elevated intraocular pressure post vitrectomy and silicon oil tamponade. CONCLUSIONS: MH in patients with BD may lead to significant visual disability. Surgical intervention does not seem to have any potential beneficial effect on the VA, probably due to significant macular ischemia and sequelae from the ocular inflammation. Medknow Publications 2011 /pmc/articles/PMC3159316/ /pubmed/21836340 http://dx.doi.org/10.4103/0301-4738.83611 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Al-Dhibi, Hassan
Abouammoh, Marwan
Al-Harthi, Essam
Al-Gaeed, Abdulrahman
Larsson, Jorgen
Abboud, Emad
Chaudhry, Imtiaz
Macular hole in Behçet's disease
title Macular hole in Behçet's disease
title_full Macular hole in Behçet's disease
title_fullStr Macular hole in Behçet's disease
title_full_unstemmed Macular hole in Behçet's disease
title_short Macular hole in Behçet's disease
title_sort macular hole in behçet's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159316/
https://www.ncbi.nlm.nih.gov/pubmed/21836340
http://dx.doi.org/10.4103/0301-4738.83611
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