Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

BACKGROUND: When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation of time without toxic effects could be one effective strategy to achieve both of these goals. The COIN trial assessed preplanned treatment holidays in advanced colorectal cancer to ach...

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Detalles Bibliográficos
Autores principales: Adams, Richard A, Meade, Angela M, Seymour, Matthew T, Wilson, Richard H, Madi, Ayman, Fisher, David, Kenny, Sarah L, Kay, Edward, Hodgkinson, Elizabeth, Pope, Malcolm, Rogers, Penny, Wasan, Harpreet, Falk, Stephen, Gollins, Simon, Hickish, Tamas, Bessell, Eric M, Propper, David, Kennedy, M John, Kaplan, Richard, Maughan, Timothy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lancet Pub. Group 2011
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159416/
https://www.ncbi.nlm.nih.gov/pubmed/21641867
http://dx.doi.org/10.1016/S1470-2045(11)70102-4

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