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Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

The minichromosome maintenance (MCM) helicase complex is essential for the initiation and elongation of DNA replication in both the eukaryotic and archaeal domains. The archaeal homohexameric MCM helicase from Sulfolobus solfataricus serves as a model for understanding mechanisms of DNA unwinding. I...

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Detalles Bibliográficos
Autores principales:	Graham, Brian W., Schauer, Grant D., Leuba, Sanford H., Trakselis, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159478/ https://www.ncbi.nlm.nih.gov/pubmed/21576224 http://dx.doi.org/10.1093/nar/gkr345

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