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Comparing binding site information to binding affinity reveals that Crp/DNA complexes have several distinct binding conformers

We show that the cAMP receptor protein (Crp) binds to DNA as several different conformers. This situation has precluded discovering a high correlation between any sequence property and binding affinity for proteins that bend DNA. Experimentally quantified affinities of Synechocystis sp. PCC 6803 cAM...

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Detalles Bibliográficos
Autores principales:	Holmquist, Peter C., Holmquist, Gerald P., Summers, Michael L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159480/ https://www.ncbi.nlm.nih.gov/pubmed/21586590 http://dx.doi.org/10.1093/nar/gkr369

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