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Systematic bias in high-throughput sequencing data and its correction by BEADS

Genomic sequences obtained through high-throughput sequencing are not uniformly distributed across the genome. For example, sequencing data of total genomic DNA show significant, yet unexpected enrichments on promoters and exons. This systematic bias is a particular problem for techniques such as ch...

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Detalles Bibliográficos
Autores principales:	Cheung, Ming-Sin, Down, Thomas A., Latorre, Isabel, Ahringer, Julie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159482/ https://www.ncbi.nlm.nih.gov/pubmed/21646344 http://dx.doi.org/10.1093/nar/gkr425

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