Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

The hypoxia-inducible factors (HIFs; isoforms HIF-1α, HIF-2α, HIF-3α) mediate many responses to hypoxia. Their regulation is principally by oxygen-dependent degradation, which is initiated by hydroxylation of specific proline residues followed by binding of von Hippel-Lindau (VHL) protein. Chuvash p...

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Detalles Bibliográficos
Autores principales: Formenti, Federico, Beer, Philip A., Croft, Quentin P. P., Dorrington, Keith L., Gale, Daniel P., Lappin, Terence R. J., Lucas, Guy S., Maher, Eamonn R., Maxwell, Patrick H., McMullin, Mary F., O'Connor, David F., Percy, Melanie J., Pugh, Christopher W., Ratcliffe, Peter J., Smith, Thomas G., Talbot, Nick P., Robbins, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2011
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159892/
https://www.ncbi.nlm.nih.gov/pubmed/21389259
http://dx.doi.org/10.1096/fj.10-177378

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