IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells

IL-10 production by CD19(+)CD5(+) B cells was investigated, by determining the expression levels of CD19, a classical B cell marker. Peripheral mononuclear cells were stained with fluorescence-conjugated anti-CD5, anti-CD19, anti-IL-10, and Annexin V. Interestingly, IL-10-producing B cells were foun...

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Autores principales: Lee, Jae Ho, Noh, Joonyong, Noh, Geunwoong, Choi, Wahn Soo, Lee, Sang Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2011
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159945/
https://www.ncbi.nlm.nih.gov/pubmed/21786452
http://dx.doi.org/10.3349/ymj.2011.52.5.851
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author Lee, Jae Ho
Noh, Joonyong
Noh, Geunwoong
Choi, Wahn Soo
Lee, Sang Sun
author_facet Lee, Jae Ho
Noh, Joonyong
Noh, Geunwoong
Choi, Wahn Soo
Lee, Sang Sun
author_sort Lee, Jae Ho
collection PubMed
description IL-10 production by CD19(+)CD5(+) B cells was investigated, by determining the expression levels of CD19, a classical B cell marker. Peripheral mononuclear cells were stained with fluorescence-conjugated anti-CD5, anti-CD19, anti-IL-10, and Annexin V. Interestingly, IL-10-producing B cells were found to be localised within the CD19(low)CD5(+) B cell subset. Apoptotic changes were also observed mainly in CD19(low) cells among B cells. Thus, CD5(+) B cells should be classified as CD19(high) and CD19(low) cells, and the immunological significance of CD19 for the IL-10 production by CD5(+) B cells requires further studies.
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spelling pubmed-31599452011-09-07 IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells Lee, Jae Ho Noh, Joonyong Noh, Geunwoong Choi, Wahn Soo Lee, Sang Sun Yonsei Med J Brief Communication IL-10 production by CD19(+)CD5(+) B cells was investigated, by determining the expression levels of CD19, a classical B cell marker. Peripheral mononuclear cells were stained with fluorescence-conjugated anti-CD5, anti-CD19, anti-IL-10, and Annexin V. Interestingly, IL-10-producing B cells were found to be localised within the CD19(low)CD5(+) B cell subset. Apoptotic changes were also observed mainly in CD19(low) cells among B cells. Thus, CD5(+) B cells should be classified as CD19(high) and CD19(low) cells, and the immunological significance of CD19 for the IL-10 production by CD5(+) B cells requires further studies. Yonsei University College of Medicine 2011-09-01 2011-07-18 /pmc/articles/PMC3159945/ /pubmed/21786452 http://dx.doi.org/10.3349/ymj.2011.52.5.851 Text en © Copyright: Yonsei University College of Medicine 2011 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Lee, Jae Ho
Noh, Joonyong
Noh, Geunwoong
Choi, Wahn Soo
Lee, Sang Sun
IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
title IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
title_full IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
title_fullStr IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
title_full_unstemmed IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
title_short IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
title_sort il-10 is predominantly produced by cd19(low)cd5(+) regulatory b cell subpopulation: characterisation of cd19 (high) and cd19(low) subpopulations of cd5(+) b cells
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159945/
https://www.ncbi.nlm.nih.gov/pubmed/21786452
http://dx.doi.org/10.3349/ymj.2011.52.5.851
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