Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

Resistance to widely used fungistatic drugs, particularly to the ergosterol biosynthesis inhibitor fluconazole, threatens millions of immunocompromised patients susceptible to invasive fungal infections. The dense network structure of synthetic lethal genetic interactions in yeast suggests that comb...

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Detalles Bibliográficos
Autores principales: Spitzer, Michaela, Griffiths, Emma, Blakely, Kim M, Wildenhain, Jan, Ejim, Linda, Rossi, Laura, De Pascale, Gianfranco, Curak, Jasna, Brown, Eric, Tyers, Mike, Wright, Gerard D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159983/
https://www.ncbi.nlm.nih.gov/pubmed/21694716
http://dx.doi.org/10.1038/msb.2011.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159983/
https://www.ncbi.nlm.nih.gov/pubmed/21694716
http://dx.doi.org/10.1038/msb.2011.31

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