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Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts

The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate...

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Autores principales: Capitán, José A., Cuesta, José A., Manrubia, Susanna C., Aguirre, Jacobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160299/
https://www.ncbi.nlm.nih.gov/pubmed/21912595
http://dx.doi.org/10.1371/journal.pone.0023358
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author Capitán, José A.
Cuesta, José A.
Manrubia, Susanna C.
Aguirre, Jacobo
author_facet Capitán, José A.
Cuesta, José A.
Manrubia, Susanna C.
Aguirre, Jacobo
author_sort Capitán, José A.
collection PubMed
description The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate in depth a model for the dynamics of a phenotypically heterogeneous population of viruses whose propagation is limited to two-dimensional geometries, and where host cells are able to develop defenses against infection. Our analytical and numerical analyses are developed in close connection to directed percolation models. In fact, we show that making the space explicit in the model, which in turn amounts to reducing viral mobility and hindering the infective ability of the virus, connects our work with similar dynamical models that lie in the universality class of directed percolation. In addition, we use the fact that our model is a multicomponent generalization of the Domany-Kinzel probabilistic cellular automaton to employ several techniques developed in the past in that context, such as the two-site approximation to the extinction transition line. Our aim is to better understand propagation of viral infections with mobility restrictions, e.g., in crops or in plant leaves, in order to inspire new strategies for effective viral control.
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spelling pubmed-31602992011-09-12 Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts Capitán, José A. Cuesta, José A. Manrubia, Susanna C. Aguirre, Jacobo PLoS One Research Article The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate in depth a model for the dynamics of a phenotypically heterogeneous population of viruses whose propagation is limited to two-dimensional geometries, and where host cells are able to develop defenses against infection. Our analytical and numerical analyses are developed in close connection to directed percolation models. In fact, we show that making the space explicit in the model, which in turn amounts to reducing viral mobility and hindering the infective ability of the virus, connects our work with similar dynamical models that lie in the universality class of directed percolation. In addition, we use the fact that our model is a multicomponent generalization of the Domany-Kinzel probabilistic cellular automaton to employ several techniques developed in the past in that context, such as the two-site approximation to the extinction transition line. Our aim is to better understand propagation of viral infections with mobility restrictions, e.g., in crops or in plant leaves, in order to inspire new strategies for effective viral control. Public Library of Science 2011-08-23 /pmc/articles/PMC3160299/ /pubmed/21912595 http://dx.doi.org/10.1371/journal.pone.0023358 Text en Capitán et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Capitán, José A.
Cuesta, José A.
Manrubia, Susanna C.
Aguirre, Jacobo
Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts
title Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts
title_full Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts
title_fullStr Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts
title_full_unstemmed Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts
title_short Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts
title_sort severe hindrance of viral infection propagation in spatially extended hosts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160299/
https://www.ncbi.nlm.nih.gov/pubmed/21912595
http://dx.doi.org/10.1371/journal.pone.0023358
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