The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

BACKGROUND: Target repurposing utilizes knowledge of “druggable” targets obtained in one organism and exploits this information to pursue new potential drug targets in other organisms. Here we describe such studies to evaluate whether inhibitors targeting the kinase domain of the mammalian Target of...

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Detalles Bibliográficos
Autores principales: Diaz-Gonzalez, Rosario, Kuhlmann, F. Matthew, Galan-Rodriguez, Cristina, da Silva, Luciana Madeira, Saldivia, Manuel, Karver, Caitlin E., Rodriguez, Ana, Beverley, Stephen M., Navarro, Miguel, Pollastri, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160303/
https://www.ncbi.nlm.nih.gov/pubmed/21886855
http://dx.doi.org/10.1371/journal.pntd.0001297

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