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Targeting renal cell carcinoma with NVP-BEZ235, a dual PI3K/mTOR inhibitor, in combination with sorafenib

BACKGROUND: Targeted therapies for metastatic renal cell carcinoma (RCC), including mammalian target of rapamycin (mTOR) inhibitors and small-molecule multikinase inhibitors, have produced clinical effects. However, most patients acquire resistance over time. Thus, new therapeutic strategies need to...

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Detalles Bibliográficos
Autores principales:	Roulin, Didier, Waselle, Laurent, Dormond-Meuwly, Anne, Dufour, Marc, Demartines, Nicolas, Dormond, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160413/ https://www.ncbi.nlm.nih.gov/pubmed/21791089 http://dx.doi.org/10.1186/1476-4598-10-90

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