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Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells

BACKGROUND: Caspase-8 is a key upstream mediator in death receptor-mediated apoptosis and also participates in mitochondria-mediated apoptosis via cleavage of proapoptotic Bid. However, the role of caspase-8 in p53- and p73-dependent apoptosis induced by genotoxic drugs remains unclear. We recently...

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Detalles Bibliográficos
Autores principales:	Liu, Juan, Uematsu, Hiroshi, Tsuchida, Nobuo, Ikeda, Masa-Aki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160414/ https://www.ncbi.nlm.nih.gov/pubmed/21801448 http://dx.doi.org/10.1186/1476-4598-10-95

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