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Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins
A large range of debilitating medical conditions(1) are linked to protein misfolding, which may compete with productive folding particularly in proteins containing multiple domains(2). With 75% of the eukaryotic proteome consisting of multidomain proteins, how is inter-domain misfolding avoided? It...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160465/ https://www.ncbi.nlm.nih.gov/pubmed/21623368 http://dx.doi.org/10.1038/nature10099 |