Paclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice

The anticancer drug paclitaxel is formulated for i.v. administration in a mixture of Cremophor EL and ethanol. Its oral bioavailability is very low due to the action of P-glycoprotein in the gut wall and CYP450 in gut wall and liver. However, proof-of-concept studies using the i.v. formulation dilut...

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Detalles Bibliográficos
Autores principales: Oostendorp, Roos L., Buckle, T., Lambert, G., Garrigue, J. S., Beijnen, J. H., Schellens, J. H. M., van Tellingen, O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160553/
https://www.ncbi.nlm.nih.gov/pubmed/20390333
http://dx.doi.org/10.1007/s10637-010-9421-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160553/
https://www.ncbi.nlm.nih.gov/pubmed/20390333
http://dx.doi.org/10.1007/s10637-010-9421-7

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