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Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
Correct replication of the genome and protection of its integrity are essential for cell survival. In a high-throughput screen studying H2AX phosphorylation, we identified Wee1 as a regulator of genomic stability. Wee1 down-regulation not only induced H2AX phosphorylation but also triggered a genera...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160579/ https://www.ncbi.nlm.nih.gov/pubmed/21859861 http://dx.doi.org/10.1083/jcb.201101047 |