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An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

BACKGROUND: Cellular senescence is an irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress and acts as an important tumour suppressor mechanism. RESULTS: To identify the do...

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Detalles Bibliográficos
Autores principales:	Rovillain, Emilie, Mansfield, Louise, Lord, Christopher J, Ashworth, Alan, Jat, Parmjit S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161017/ https://www.ncbi.nlm.nih.gov/pubmed/21740549 http://dx.doi.org/10.1186/1471-2164-12-355

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