GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy

Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression. Multiple linkage and population association studies have connected the bromodomain-containing gene BRD2 to forms of IGE. In mi...

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Detalles Bibliográficos
Autores principales: Velíšek, Libor, Shang, Enyuan, Velíšková, Jana, Chachua, Tamar, Macchiarulo, Stephania, Maglakelidze, Giorgi, Wolgemuth, Debra J., Greenberg, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161054/
https://www.ncbi.nlm.nih.gov/pubmed/21887291
http://dx.doi.org/10.1371/journal.pone.0023656

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