The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53- Independent Manner in Colon and Breast Cancer Cells

The chemotherapeutic drug 5-FU is widely used in the treatment of a range of cancers, but resistance to the drug remains a major clinical problem. Since defects in the mediators of apoptosis may account for chemo-resistance, the identification of new targets involved in 5-FU-induced apoptosis is of...

Descripción completa

Detalles Bibliográficos
Autores principales: García, María Angel, Carrasco, Esther, Aguilera, Margarita, Alvarez, Pablo, Rivas, Carmen, Campos, Joaquin María, Prados, Jose Carlos, Calleja, Miguel Angel, Esteban, Mariano, Marchal, Juan Antonio, Aránega, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161074/
https://www.ncbi.nlm.nih.gov/pubmed/21887339
http://dx.doi.org/10.1371/journal.pone.0023887

Ejemplares similares

Ejemplares similares